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The sequence of the C terminus of 5-helix (H387L394) is shown in the middle in gold

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Using Fraxel to treat patients with darker skin tones can result in unwanted side effects, including exacerbation of hyperpigmentation, as a result of the laser interacting with skin pigment

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While nausea cannot always be completely prevented, eating smaller and more frequent meals, avoiding high-fat and greasy foods, staying well-hydrated, and following a gradual dose escalation schedule can significantly reduce symptoms and improve tolerability