semaglutide makes me feel terrible Fatigue: Feeling Weak on Semaglutide Does Semaglutide Make You Sleepy?

As well as turning down the dial on food noise, some users have reported positive effects on mood, while others feel emotionally flat

We have seen an increase in these scenarios at UT Southwesterns Ob/Gyn and Weight Wellness clinics, too

The STEP UP Phase 3b clinical trial, published in The Lancet Diabetes and Endocrinology in 2025, enrolled over 1,400 adults with obesity and without diabetes

This comparison allows patients to see why tirzepatide seems to have a more adaptable upper range, whereas semaglutide sticks to a steadier and more consistent progression

Many patients prefer taking their first shot on a Friday evening