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1998), sequestration of heavy metals (Cobbett and Goldsbrough 2002) and defense against ROS (Foyer and Noctor 2005a)

however, risk escalates significantly when combined with insulin or secretagogues like glipizide or meglitinides

In addition, combination of linsitinib with erlotinib did not improve the progression-free survival and overall survival in patients with advanced non-small cell lung cancer, compared to erlotinib alone (Table 2)