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MNSI, Michigan Neuropathy Screening Instrument Examination

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus under the brand name Mounjaro and for chronic weight management under the brand name Zepbound

Shaking creates shear forces, rapid mechanical stress that breaks peptide bonds

"I think that's one of the biggest concerns from the FDA side," LaValle, who chairs the International Peptide Society, said