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Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)

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For larval testing, we assessed swimming speed from 5 to 8 dpf using DanioVision after drug treatment

Prescribers considering this formulation should be aware of the patient's overall health status, including any other medications being taken, to avoid potential drug interactions

No in vitro or in vivo study has demonstrated CYP3A4 inhibition or induction by ipamorelin