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3.1.3 DON DON (6-diazo-5-oxo-l-norleucine), a glutamine analog, irreversibly inhibits various glutamine utilization enzymes, such as glutaminase and glutamine synthetase, by forming covalent bonds with nucleophilic residues on the active site of the enzyme (Rajagopalan and DeBerardinis, 2011
& Murakami, A
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Gamelin E, Boisdron-Celle M, Gurin-Meyer V, Delva R, Lortholary A, Genevieve F, et al
Many patients prescribed glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes or weight management wonder whether these medications will be detected on routine blood work
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