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On the question of raw, proven efficacy for photoaging, the honest answer is that tretinoin has the stronger evidence base but the picture is more nuanced than a simple winner-takes-all verdict

Another follow-up trial called SEER-3 did not show a clear difference in eye healing compared to the placebo

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Rather, they represent two sides of the same coin, interconnected through the intricate, bidirectional communication network known as the gut-brain axis

In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999