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In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]

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Who 5-Amino-1MQ Is For and Who Should Avoid It 5-Amino-1MQ has no FDA-approved use, so there is no formal eligibility list

The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested