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Adipokines such as leptin and adiponectin are involved in IR (41)

Kanishka Sharma, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy

The results are temporary and may gradually fade, especially without ongoing maintenance doses

The oncoprotein c-Myc regulates nucleotide metabolism ( OTHER REGULATORS OF THE PENTOSE PHOSPHATE PATHWAY It has been shown that the activation of mammalian target of rapamycin complex 1 (mTORC1) increases the metabolic flux through both glycolysis and the oxidative arm of the pentose phosphate pathway ( In contrast, the non-oxidative arm of the pentose phosphate pathway is enhanced in the presence of oncogenic Kras (Kras G12D ) in pancreatic tumors (Ying et al., 2012)

Moreover, ROS and RNS increase the propensity of aSYN to aggregate and worsen the effects of genetic mutations and environmental pollutants on the mitochondria [37]