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A major portion (91.6%) of stomach-projecting NG neurons expressed GHSR, supporting the previous finding of GHSR expression in 98% of tension-sensitive NG neurons that were retrogradely traced from the stomach 37

Upon activation of the GLP-1 receptor, cAMP levels increase, which activates the cAMP response element-binding protein (CREB) ( Furthermore, GLP-1R activation increases cAMP and alters downstream signaling pathways, including PKA, PI3K, PKC, and AKT, all of which contribute to its neuroprotective effects (Zhou et al., 2019)