In mammalian models, exposure has been reported as concentrations in drinking water (e.g., 0.550 g/mL for 90 days) [134] and as oral doses spanning from mg/kg/day regimens to very high bolus doses (e.g., up to 2000 mg/kg by gavage) [141]
Mitochondrial dysfunction has been demonstrated to exert a deleterious effect on the development of embryos, resulting in aberrant apoptosis and autophagy
The final solution should be perfectly clear, with no floating particles
Cells were seeded at a density of 2 10 4 per well in 96-well transparent plates 24 h before treatment
Posttranslational modifications, cellular stress, or apoptosis can lead to the production of neoantigens or the abnormal presentation of normal self-proteins (e.g., insulin, GAD65, IA-2, ZnT8)