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It is well established that oxygen deficiency, leading to a hypoxic microenvironment, in the TME limits the efficacy of radiotherapy

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Des(13)IGF-1 is a naturally occurring, endogenous truncated analogue of Insulin-like Growth Factor-1 (IGF-1), lacking the first three amino acids at the N-terminus of IGF-1, giving it a total of 67 amino acids compared to the 70 of native IGF-1

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Callose deposits were identified by their characteristic bright blue fluorescence