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(277) further revealed that fish and seafood protein intake was significantly associated with a 16% reduction in CKD risk (RR = 0.84, 95% CI: 0.740.94), potentially attributable to the anti-inflammatory effects of omega-3 fatty acids

This makes evolutionary sense for surviving famine but creates frustrating fatigue during intentional weight loss

As an example pathway to decrease conditioned consummatory behavior, VTA GLP-1R signaling potentially controls for palatable food intake by modulating the rewarding value of the ongoing meal while having fewer effects on between-meal satiety processes