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Anaphylactic shock and death have been reported after parenteral vitamin B 12 administration

National Center for Immunization and Respiratory Disease

Besides, inhibition of HDACs and histone hyperacetylation, the neuroprotective effect of HDACi may also involve multiple mechanisms of action, involving activation of the kinase pathway by extrinsic signals (Kim et al., 2007) or microglialmediated inflammation (Peng et al., 2005), as reported earlier for valproic acid