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(2022), it was observed that MOTS-c therapy and regular aerobic exercise led to alterations in pathogenic genes, with overlapping effects on 24 genes related to angiogenesis, inflammation, and apoptosis [14]

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PMID: 31963141

Overall, the transition is usually motivated by: Plateauing on semaglutide Interest in a dual GLP-1/GIP mechanism Provider-recommended adjustments A desire to explore alternative dosing structures Even with these benefits, switching requires careful planning, since the two medications differ significantly in potency and tolerability