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Clinical outcome association analyses To determine whether improvements across clinical symptom domains (urinary, gait, cognitive) were interrelated following shunt surgery, each domain was binarized as improved or not improved according to predefined clinical criteria

Lang KS, Roll B, Myssina S, Schittenhelm M, Scheel-Walter HG, Kanz L, et al

Adiponectin, a separate hormone that aids in blood sugar and fat usage, increased at weeks 24 and 48 at doses of 4 mg or higher

Suspected adverse reactions can be reported through the MHRA Yellow Card scheme to support ongoing medication safety monitoring

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