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However, high-intensity prolonged exercise may lead to increased intestinal permeability and systemic inflammation, disrupting microbial balance (Mailing et al., 2019)

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MC3R activation contributes to the pro-erectile and pro-arousal effects observed in both sexes, the same pathway activated by PT-141 (bremelanotide), which is a direct metabolite of Melanotan-2 without the tanning effect