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SURPASS-CVOT, published in two stages the primary outcome in NEJM in December 2025, and a follow-up cardiorenal analysis in JAMA Cardiology in March 2026

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Interestingly, we also observed an unusual amino acid inserted the HHxxxxDG motif of CesA_C2 and Vlm1_C2 (Fig

Leptin levels decrease with fat mass reduction, potentially increasing hunger signals, whilst ghrelin (the 'hunger hormone') may rise, counteracting the appetite-suppressing effects of tirzepatide

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