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Consequently, NPs derived from herbs, which are characterized by their low toxicity and accessibility, are emerging as safer alternatives for treating such harmful diseases [150]

Abstract Objectives To evaluate the effects of a very-low-calorie diet (VLCD) on insulin resistance (IR), metabolic gene expression, and fatty acid profiles in obese patients (body mass index [BMI] 30 kg/m 2 ) undergoing bariatric surgery compared to age- and sex-matched nonobese controls (BMI 25 kg/m 2 ) undergoing elective abdominal surgery

If the treatment causes a detrimental shift in microbial composition, leading to adverse effects like gastrointestinal distress or immune suppression, healthcare providers could intervene by adjusting the treatment regimen or introducing probiotic interventions to restore microbial balance

PMID 10760156

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