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Mutagenesis Hydroxocobalamin was negative in the following mutagenicity assays: in vitro bacterial reverse mutation assay using Salmonella typhimurium and Escherichia coli strains , an in vitro assay of the tk locus in mouse lymphoma cells, and an in vivo rat micronucleus assay

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The increased pulse rate associated with tirzepatide was more pronounced in this cohort than in previous global studies, although its clinical significance remains uncertain