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concurrently, BNIP3 recruits Parkin to mitochondria to initiate autophagic flux, whereas NIXas a ubiquitination substrate of Parkinundergoes conformational remodeling post-modification to specifically engage adaptor protein NBR1, ultimately enabling targeted autophagic degradation of compromised mitochondria (Wang et al., 2023)
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Low molecular weight drugs Enterohepatic recycling After initial distribution and metabolism, some drugs are excreted into the bile, enter the intestine, and are then reabsorbed back into circulation
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