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doi: 10.3389/fimmu.2024.1537909

9 During the day, bone resorption is suppressed, presumably related to food intake and secretion of intestinal-derived hormones, whereas resorption increases at night and during periods of extended fasting ( Figure 2 )

Conclusion This comprehensive review highlights the therapeutic potential of GLP-1 and its analogs in the management of metabolic disorders, particularly T2DM

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In the diabetes TRIUMPH-2 trial, reported side effects included: Diarrhea (around 27 to 34 percent of participants, depending on the dose) Nausea (14 to 28 percent) Constipation (14 to 17 percent) Decreased appetite (6 to 17 percent) Vomiting (6 to 16 percent) In the TRIUMPH-3 trial for adults with severe obesity and heart disease, participants reported: Diarrhea (around 24 to 30 percent of participants, depending on the dose) Nausea (22 percent) Constipation (16 to 18 percent) Decreased appetite (14 to 15 percent) Hyperglycemia, or high blood sugar (3 to 4 percent) The high rates of diarrhea surprised Ali