Older adults, those with certain digestive conditions, and people who take some common medications may get very little from an oral pill, no matter how high the dose
In fact, GLP-1 use was linked to a 13% reduction in a person's risk of premature death from any cause, the research showed
These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i
If medications like Ozempic or Wegovy can be developed as macrocyclic drugs, the aim is to achieve the same outcomes as their injectable counterparts, whether for blood glucose control or weight loss, she adds
Emerging roles for the gut microbiome in autism spectrum disorder