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Nevertheless, supplementation with 2 mg/d folic acid, 25 mg/d vitamin B6, and 400 g/d B12 during 6 months significantly decreased the homocysteine levels, severity, and disability of migraine attacks (60)

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Individual non-responder: Small percentage of individuals don't respond to specific interventions regardless of quality or dosing

10.1104/pp.008243 Plant Physiol