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Inflammatory cytokines, such as IL-17 and TNF-, are particularly important in the pathogenesis of HS (217)

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Specific triggers for medical consultation include achieving less than 5% body weight reduction after reaching the maintenance dose (for Wegovy, after 12 weeks at 2.4 mg as per FDA labeling), prolonged weight loss plateau despite adherence, or intolerable side effects preventing dose escalation to therapeutic levels

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