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Physical examination includes vital signs assessment for hemodynamic stability, abdominal examination for tenderness or masses, and digital rectal examination to identify anorectal pathology and characterize stool appearance

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If hives are widespread or accompanied by other symptoms (swelling of the face or throat, difficulty breathing, rapid heartbeat), seek emergency medical attention immediately

the suitable promoter can be selected from T7, TRC, TRP, BAD, LacUV5 or their derivatives or combination thereof