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GLP-1RAs (and their offshoots that add agonists of other key metabolic regulation substances) have shown particular promise in patients with obesity-related cardiovascular and metabolic complications, offering synergistic benefits that extend beyond weight loss

Both produce dose-dependent gastrointestinal effects during escalation

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In addition, disrupting the gut microbiota while inhibiting the TMAO biosynthetic pathway mitigates kidney damage in mouse models of CKD

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