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What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
By doing so, it helps keep the LES closed when it should be, reducing the number of reflux episodes
Gastrointestinal Symptoms: Common side effects include nausea, vomiting, diarrhea, and abdominal discomfort
PMC 340185
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