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It is not metabolized by the liver, does not undergo significant protein binding, and its clearance is highly dependent on renal function ( TABLE 1 Pharmacology and mechanistic basis of Metformins cardioprotective actions

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The GB has motor function that allows for 2030% emptying at 1- to 2-h intervals during a fasting state and 7080% emptying after a meal

Bei stark bergewichtigen Personen ist dieser Effekt anfangs gering, da weniger Essen verbunden ist mit strkerem Fettabbau