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These two events are mechanistically separable: extracellular domain binding affinity does not predict transmembrane domain activation efficiency, and mutations in the extracellular domain can selectively abolish -arrestin recruitment while preserving cAMP production

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Kim W, Kim SK, Nabekura J

Placebo Controls (00:21:36) Hormone Release & Placebo Effect, Paired Associations (00:28:52) Conditioning Effect & Insulin

J Am Coll Cardiol 64:22222231