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These mediators can induce the production of MMPs and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) by chondrocytes and further degradation of the cartilage, contributing to a cycle of inflammation and disease 7,10

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If side effects like nausea are the concern, talking with a healthcare provider about dose adjustments is safer than skipping weeks, since lower weekly doses provide steadier, gentler medication exposure than double-strength doses every 14 days