If your vial accidentally freezes, discard it
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The injection vehicle is carefully selected to ensure compatibility with both active ingredients while maintaining appropriate pH, osmolality, and other physical characteristics necessary for subcutaneous administration
As explained in the resource, semaglutide typically begins at 0.25 mg weekly and increases gradually to a maximum of 2.4 mg weekly for weight management, with titration occurring every four weeks
Head-to-head comparison The cleanest comparison so far is SURPASS-2, which pitted tirzepatide against semaglutide 1 mg in adults with type 2 diabetes (not the obesity dose, but still the most rigorous head-to-head we have)