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Estos medicamentos imitan la accin de una hormona intestinal que, en condiciones normales, estimula la secrecin de insulina de forma dependiente de la glucosa, suprime la secrecin de glucagn, reduce el apetito, ralentiza el vaciamiento gstrico y mejora el control metablico general

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Injectable forms may require higher doses and should be administered by healthcare professionals

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In addition, reduced SCFA produced by the microbiota leads to inhibition of histone deacetylation and weakened post-translational modification of histones in the gut, which promotes epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells and participates in renal fibrosis of DN (61)