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Depending on the chemotherapy regimen, severe CIPN (i.e., symptoms that limit self-care activities of daily life or are life threatening), classified as grade 3 or 4, can occur in up to 35% of patients and symptoms can be so bothersome that they force dose-modifications or treatment discontinuation (Lustberg 2024

Chronic sympathetic dominance (the "fight-or-flight" state) maintains cortisol elevation, which directly suppresses secretory IgA your gut's primary antibody defence against Candida

Consoli A, Nurjhan N, Capani F, Gerich J

doi: 10.1007/s11033-019-04801-y

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