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Your body burns more calories at rest while on tirzepatide because the medication influences how your brain manages energy balance

DSIP administration has been reported in rodent models to attenuate stress-induced elevations of ACTH and corticosterone and to modify behavioral responses to acute stressors (Graf & Kastin, 1984)

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

and then top up with a supplement if you know you are deficient through a blood test or urinary organic acid test

Exposed to constant stress, these normally helpful hormones can become dysregulated and drive blood pressure up