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More comprehensive approaches should be incorporated to elucidate specific immune signaling pathways involved and the interaction between gut microbiota, enteric nervous system and immune activation during IBS pathogenesis (Lazaridis and Germanidis, 2018)

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Stand on a step with heels hanging off the edge Rise up on toes using both legs Shift weight to affected leg only Slowly lower heel below step level over 3 to 5 seconds Return to starting position using both legs Perform 15 repetitions, 3 sets, twice daily Expect some discomfort during exercise

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