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PAR2 flox [ B6(Cg)-F2rl1 tm3.1Wmrf /Tarc ] were used as wild-type controls (PAR2-WT)

Angewandte Chemie International Edition 54, 28212824 (2015)

CaOx crystal deposition impairs fatty acid metabolism in TECs, leading to insufficient ATP production, apoptosis, and necrosis

The third pathway is proline utilisation which occurs in mitochondria where proline is oxidised to pyrroline-5-carboxylate by mitochondrial proline dehydrogenase ( PUT1 ) which, in turn, is further oxidised to glutamate by 1-pyrroline-5-caboxylate dehydrogenase ( PUT2 ) 19