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Two independent mechanisms of appetite suppression , in a hypothetical research context, the combination could be supra-additive

166 Specifically, SGLT2 inhibitors alleviate fibrosis by improving blood sugar and lipid levels, enhancing the physiological functions of hepatocytes and HSCs, modulating intestinal flora, and facilitating vascular remodeling

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Tirzepatide, initially approved for managing type 2 diabetes, is currently under investigation for its promising weight loss benefits

Accepting the premise that circulating GLP1 does not enter the CNS beyond the circumventricular organs is a prerequisite to assuming that GLP1 is released from PPG neurons as a neurotransmitter or neuromodulator with locally restricted and potentially disparate actions