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The latter designation derives from its original characterization in tumor cells, which were resistant to a variety of chemotherapeutic agents by virtue of the high expression of this efflux pump resulting in low and ineffective intracellular concentrations of the drug

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In addition to inflammasome activation, IL-1 promotes inflammation by boosting bone marrow-derived leukocyte mobilization and liver-derived acute-phase protein production ( IL-6 T cells and macrophages secrete the cytokine IL-6, essential for host defense

Regular maintenance sessions may be required to sustain the desired skin tone