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The route of administration does not change the safety or compatibility of the combination

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However, here is why you might want to skip the psyllium husk if you are on a weight-loss medication: Delayed Gastric Emptying: Medications like Ozempic, Wegovy, Mounjaro, Zepbound and Retatrutide intentionally slow down your digestive tract

Annual Rev Nutr 1995;15:133-59.