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doi: 10.1016/j.biomaterials.2025.123239 150 DengYLuJLiWWuAZhangXTongWet al

Through comparative analysis of three geographically diverse gut metabolomic datasets (four case-control comparison) encompassing IBD cohorts and non-IBD controls (including patients with varying disease activity states), we identified significant pathway enrichment in aromatic amino acid metabolism, particularly involving tyrosine, phenylalanine, and tryptophan catabolism (Fig

Studies may involve incubating cell lysates or microsomal fractions with various xenobiotics in the presence of GSH and glutathione S-transferases (GSTs) to characterize metabolic pathways and identify conjugated metabolites