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NICE guidance recommends GLP-1 receptor agonists for type 2 diabetes when triple therapy is insufficient and specific BMI criteria are met, or for weight management in adults with BMI 30 kg/m (or 27 kg/m with comorbidities) through specialist services

If side effects are too severe at a particular dose, your provider may extend the time at that dose before increasing, or may adjust the escalation schedule

The major pathways involved are insulin signaling defects, AGE-RAGE axis activation, PI3K/AKT/FOXO1 dysregulation, JNK pathway stimulation, and Peroxisome proliferator-activated receptor gamma (PPAR) dysfunction [60]

What to do next

My doctor explained that taking GLP-1s is a lifelong process