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Characteristic features of metabolic dysfunction (insulin resistance, diabetes mellitus type 2 [T2DM], and hyperlipidemia) appearing in young subjects are also tightly associated with fatty liver, besides fatness [73]
For example, research into the molecular mechanisms underlying the effects of specific genetic polymorphisms on collagen synthesis and degradation can inform the development of pharmacological agents or gene therapies to enhance ligament strength and repair
The methylation of the GPx3 promoter was also observed in hepatocellular carcinoma (HCC) tissue [101] and gastric carcinoma [102], possibly leading to subsequent carcinogenesis and cancer cell progression
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