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Given their vital role, cells have evolved mechanisms to generate fatty acids from alternative carbon sources, through a process known as de novo lipogenesis (DNL)

At the same time, low oxygen can also affect the antioxidant defense system, such as reducing the activity of enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), making it more difficult for cells to clear ROS, thus exacerbating oxidative stress (Zaarour et al., 2023)

Gene expression remained normal in unstressed plants

15 , opioids increase A-a gradients by impairing ventilation-perfusion ratios in the lungs (ventilation-perfusion mismatch)

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