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Advanced Retention Systems (Gels and Nanocrystals) To transition from systemic to topical therapy, formulations must overcome rapid tear fluid washout

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Solsona-Vilarrasa E., Vousden K.H

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Nair AB, Dalal P, Kadian V, Kumar S, Kapoor A, Garg M, et al

Mechanistically, pterostilbene treatment of RBL-2H3 cells increased phosphorylation of Serine/Threonine Kinase 11 (LKB1), AMPK, and acetyl co-A carboxylase, and decreased proteins involved in FcRI-mediated signaling, including phosphorylated p38, ERK, JNK, IKK and mTOR, suggesting pterostilbene both activates the LKB1/AMPK pathway and inhibits FcRI signaling [209]