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In the context of semaglutide use, the medications effects on gastric emptying and gastrointestinal motility may exacerbate or contribute to heartburn symptoms

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Notably, GLP-1 receptor agonists (GLP-1 RAs) can cross the blood-brain barrier, and in preclinical PD models, GLP-1 RAs have been shown to improve motor function and provide neuroprotection [10, 11]