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The most commonly reported effects during the initiation phase include: Injection site reactions: Mild redness, itching, or a small bump at the site that resolves within hours

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In the RCTs, prebiotics showed similar clinical efficacy to mesalamine, and synbiotics, combined with probiotics and prebiotics, could also significantly decrease the CAI, the levels of intestinal mucosal inflammatory cytokines and fecal calprotectin, but not DAI [308,309,310,311,312]

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