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Studies have demonstrated that endothelial NAD+ levels decrease by 40-60% during aging, correlating with reduced nitric oxide bioavailability and impaired vasodilation

Other organ systems, such as the digestive and cardiovascular systems, also contain peripheral nerves, so CIPN can also lead to symptoms such as swallowing problems, constipation, and heart arrhythmias (Burgess 2021)

It also restored the decreased concentration of the primary excitatory neurotransmitter N-methyl-D-aspartate when administered to older mice [95]

Cost differences are substantial, with IV therapy costing $2,000-$3,200 for an 8-week course versus $30-$240 for oral supplements

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