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Unexpectedly, TMLHE, the first and rate-limiting enzyme in de novo carnitine synthesis, was the only one of the top five genes to drop out in both CCNE1-driven cell lines ( Fig

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NAD + plays a crucial role in several physiological conditions such as neurological disorders, diabetes, aging, oxidative stress and neurodegenerative diseases 20,21,22,23,24,25,26

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