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The pen is a single-use device and must be disposed of immediately after injection by placing it into an FDA-cleared sharps disposal container

4 The New England Journal of Medicine, November 11, 2023

You should expect: Regular weight and BMI measurements Periodic thyroid function tests (typically 68 weeks after starting GLP-1 therapy, after significant weight loss, and then every 612 months) Assessment of side effects and treatment tolerance Review of overall health status and comorbidities When to seek medical advice : Contact your GP promptly if you experience severe or persistent nausea and vomiting, signs of pancreatitis (severe abdominal pain), right upper abdominal pain with fever or jaundice (possible gallbladder disease), symptoms suggesting worsening thyroid function, or any concerning new symptoms

Severity typically decreases after week 2-3 as your autonomic nervous system recalibrates to lower blood sugar levels and slower digestion

The authors are grateful to their sincere appreciation to the Researchers Supporting Project Number (RSP-2021/356), King Saud University, Riyadh, Saudi Arabia